Graduate Faculty Directory
Adeboye Adejare
Department of Pharmaceutical Sciences
Education
- PhD (Ohio State University)
- BS, MS (University of Iowa)
Title(s)
Chair, Department of Pharmaceutical Sciences
Director, Pharmacology and Toxicology Graduate Program
Faculty Appointments
Professor of Pharmaceutical Sciences
Research Professor of Medicinal Chemistry
Research Interest
Probing neurodegeneration observed in stroke and Alzheimer's disease through design and synthesis of small organic molecules, in vitro models of drug absorption and ability cross blood brain barrier, drug targeting, pharmaceutical profiling, and chemistry of fluoroaromatic compounds
Synopsis
My group is interested in the areas of design and syntheses of small organic molecules to probe neurodegeneration. We are also interested in in vitro models of drug absorption and ability to cross the blood brain barrier, drug targeting, pharmaceutical profiling, and chemistry of fluoroaromatic compounds. The major therapeutic ideas we focus on are N-methyl-D-aspartate (NMDA) receptor antagonists and gamma-secretase inhibitors. These two mechanisms have been implicated in neurodegeneration as observed in stroke and Alzheimer’s disease. Our research was/is funded by the National Institutes of Health, the Office of Naval Research, and several pharmaceutical companies. These efforts have resulted in over 30 publications, a patent, and over 80 presentations at meetings, including invited presentations at national and international conferences. Several students from my group have received graduate degrees (MS and PhD) and are employed in academia and the pharmaceutical industry.Publications & Presentations
E. Buyukbingol, A. Sisman, F. Alparslan and A. Adejare, “Adaptive neuro-fuzzy inference system (ANFIS): A new approach to predictive modeling in QSAR applications: A study of neuro-fuzzy modeling of PCP-based NMDA receptor antagonists”, Bioorganic and Medicinal Chemistry, 15, 4265-4282 (2007).
- S. Sun and A. Adejare, “Fluorinated Molecules as Drugs and Imaging Agents in the CNS”, Current Topics in Medicinal Chemistry, 6, 1457-1464 (2006).
- “Syntheses of Novel Indole Lipoic Acid Derivatives and Their Antioxidant Effects on Lipid Peroxidation,” A. S. Gurkan, A. Karabay, Z. Buyukbingol, A. Adejare, and E. Buyukbingol, Archiv der Pharmazie, 2005, 338, 67–73.
- “A Randomized Crossover Study Investigating the Influence of Ranitidine or Omeprazole on the Pharmacokinetics of Cephalexin Monohydrate,” K. Madares-Kelly, P. Michas, M. George, M. P. May, and A. Adejare, Journal of Clinical Pharmacology, 2004, 44, 1391–1397.
- “Membrane Permeability Related and Physicochemical Properties of a Novel gamma-Secretase Inhibitor,” A. M. El-Gendy and A. Adejare,International Journal of Pharmaceutics, 2004, 280, 47–55.
- “Crystal Structures of the Dipeptides Glycyl-D-Glutamine and Cyclo(Glycyl-L-Glutamine),” M. R. Caira, E. Buyukbingol, A. Adejare, and W. R. Millington, Analytical Sciences, 2002, 18, 1175–1176.
- “Synthesis of Fluorinated Phencyclidine Analogs,” A. M. Ogunbadeniyi and A. Adejare, Journal of Fluorine Chemistry, 2002, 114, 39–42. “Halogens Halt Aromatic Group Migration in Baeyer-Villiger Oxidation,” A. Adejare, J. Shen, and A. M. Ogunbadeniyi, Journal of Fluorine Chemistry, 2000, 105, 107–109.
Contact Information
Office:
Pharmacology/Toxicology Center
Room 241
Mailbox # 80
Phone: 215.596.8944
Email: a.adejar@usp.edu
